In Situ Cross-Linking of Elastin-like Polypeptide Block Copolymers for Tissue Repair

Affinity-Modulation Drug Delivery Using Thermosensitive Elastin-Like Polypeptide Block Copolymers

Affinity-Modulation Drug Delivery Using Thermosensitive Elastin-Like Polypeptide Block Copolymers by Andrew J. Simnick Department of Biomedical Engineering Duke University Date:_______________________ Approved: ___________________________ Ashutosh Chilkoti, Ph.D., Supervisor ___________________________ Mark W. Dewhirst, Ph.D., D.V.M. ___________________________ Kam W. Leong, Ph.D. _____________...

Leukocyte Response to Elastin-like Polypeptide Coatings

Elastin-like polypeptide based hydroxyapatite bionanocomposites.

In nature, organic matrix macromolecules play a critical role in enhancing the mechanical properties of biomineralized composites such as bone and teeth. Designing artificial matrix analogues is promising but challenging because relatively little is known about how natural matrix components function. Therefore, in lieu of using natural components, we created biomimetic matrices using geneticall...

In Situ Cross-Linking of Polyanionic Polymers to Sustain the Drug Release from Theophylline Tablets

The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...

In Situ Cross-Linking of Polyanionic Polymers to Sustain the Drug Release from Theophylline Tablets

The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...